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MessagePosté le: Mar 27 Mar 2018 - 10:39    Sujet du message: RNA delivers instructions an Répondre en citant

WTA ranked #1 Serena Williams has been an advisory staff member of Wilson Sporting Goods for a long time Patrice Evra France Jersey , and the company has recently honored her with an Autograph racket. The model is called The Blade SW 104 and is already one of the most anticipated Autograph rackets for collectors, fans, and avid players. Williams is expected to debut thenew racket in Australia at the start of the 2017 season.

According to Wilson, the Blade SW 104 Autograph racket honors Serena not just as an athlete and a tennis icon, but also a friend and partner. Williams has often been described game-changer in its truest form; she has certainly rewritten tennis history and continues to inspire younger players. The Autograph racket is the most prestigious honor Wilson gives athletes.

Williams, who says that she has always played using Wilson rackets since she was a young girl, considers this honor as one of the greatest in her career. She is thrilled that players from all over the world—of varying ages and skills—get to play using a Wilson racquet bearing her signature. She hopes that people see that the Blade SW 104 reflects her perseverance, passion, and drive—and that it ultimately encourages players to make their dreams come true.

It’s hard not to do a double take when you see the 2017 Blade SW 104 Autograph racket. Your eyes will be drawn to the simple, clean, and bold aesthetic. The high performance matte paint (specially engineered) used on the Serena Williams racquet is called Black Velvet, and it provides a smooth light-absorbing finish that drastically improves the feel of the product. Wilson expects players to appreciate this tactile experience. The racket likewise features electric green accents (also seen on other rackets in the Blade collection). Williams customized her Autograph racket with special gold accents for her initials and signature. The ‘Blade’ name is written in gold chrome letters. And as always, there is a red Wilson-branded butt cap.

The Blade SW 104 Autograph racket integrates a revolutionary material called Countervail, which gives players better control while decreasing fatigue and allowing quick recovery—all without sacrificing feedback, stiffness, or feel. Countervail—which was originally developed for NASA—uses a patented carbon fiber architecture. The integration of Countervail directly into the Blade SW 104 provides players with the same feel of a traditional tennis racket but much less vibration energy. Countervail is exclusive to Wilson.



SAN FRANCISCO, Aug. 21 (Xinhua) -- Researchers at Stanford University have used modern techniques to study how proteins are directed to various areas within a cell, and with new insight into one of the fundamental mechanisms of protein delivery, are able to revise the understanding of cellular mechanisms.

A protein's journey begins when a piece of messenger RNA delivers instructions and a command to a ribosome, one of the tiny bulbous protein factories within the cell. The ribosome follows the recipe encoded on the mRNA, which itself was translated from the genes within DNA, and manufactures the specific protein.

Research in the early 1970s revealed that the first part of many new proteins is a signal that makes the ribosome pump the product into another cellular structure called the endoplasmic reticulum (ER). A "signal recognition particle" (SRP) latches on to the protein signal to help pilot it to the ER; the SRP also momentarily stops protein production, with the ribosome kicking back into action once it reaches the ER and the SRP has moved along.

However, "our data supported the role for SRP, but our experiments did not support this model," said Judith Frydman, a professor of biology and of genetics at Stanford and a co-author of a study published in the recent issue of journal Nature. "This is what is so cool about this study. We found that in fact SRP works through a very different and completely unexpected mechanism."

Using modern techniques and instruments that allowed them to observe the mechanism in higher resolution than previously possible, Frydman and her colleagues found that the mRNA contains a little bit of information that the SRP recognizes before protein production begins, and that the SRP waits at the exit site of the ribosome before the protein even emerges.

"It's almost prescient; it already knows before it comes and just steps right in," Frydman was quoted as saying by a Stanford news release.

The researchers also found that the SRP didn't halt protein production at all, as was previously believed. And the dual discovery is both important and interesting, Frydman said, because how and when proteins reach the membranes within the cell has dire consequences.

Very important processes rely on the fidelity of where proteins have to go, she said, and cells need to secrete proteins faithfully. If a particular protein stays in the cytoplasm, it could aggregate and lead to loss of healthy function or the accidental gain of unhealthy function. These gains or losses are typical of a variety of diseases, such as cystic fibrosis, cancer and Alzheimer's disease.

In addition, as many proteins that are important pharmaceutically are made in large part by targeting them to this secretory pathway, according to Frydman, "they have also been designed relying on this classical model. Having a better understanding of this process could really enhance the process of designing new pharmaceuticals."

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